ASSESSMENTS OF PLASMA HIV RNA AND CD4 CELL COUNTS AFTER COMBINED PNEUMOVAX(R) AND TETANUS TOXOID VACCINATION - NO DETECTABLE INCREASE IN HIV REPLICATION 6 WEEKS AFTER IMMUNIZATION

The influence of simultaneous vaccination with Pneumovax and tetanus t oroid on plasma human immunodeficiency virus (HIV) RNA and CD4 cell co unts was assessed in patients with HIV infection. Six weeks after immu nization plasma HIV RNA did not differ significantly from baseline val ues. A slight decline in CD4 cell counts after vaccination was detecte d. There was no correlation between the serological responses to pneum ococcal vaccination and baseline CD4 cell counts, changes in HIV RNA o r CD4 cell counts. In conclusion, immunization did not induce an incre ase in viral replication detectable 6 weeks after immunization.