SCEDOSPORIUM APIOSPERMUM PNEUMONIA AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION

Although opportunistic infections after bone marrow transplantation (B MT) are very common, only five cases of Pseudallescheria boydii infect ion have been reported in the literature, two of which were autopsy fi ndings. A case of Scedosporium apiospermum infection after BMT, treate d initially with amphotericin B (total dose of 2.5 g) and then with it raconazole (for 25 days), is reported here. When the patient failed to improve, Scedosporium apiospermum pneumonia was diagnosed and therapy was changed, The patient was treated successfully with miconazole (60 0 mg/8h for 32 days) and ketoconazole (200 mg/8h for 7 days) plus surg ery.