Hr. Jager et al., ASSESSMENT OF BRAIN CHANGES WITH REGISTERED MR BEFORE AND AFTER BONE-MARROW TRANSPLANTATION FOR CHRONIC MYELOID-LEUKEMIA, American journal of neuroradiology, 17(7), 1996, pp. 1275-1282
Citations number
23
Categorie Soggetti
Clinical Neurology","Radiology,Nuclear Medicine & Medical Imaging
PURPOSE: To determine the frequency and nature of changes to the brain
resulting from chemotherapy, radiation therapy, and bone marrow trans
plantation for chronic myeloid leukemia and to compare the sensitivity
of conventional and registered MR scans for detecting these changes.
METHODS: In 15 patients, conventional T1-weighted, T2-weighted, and fl
uid-attenuated inversion recovery MR sequences, as well as T1-weighted
radio frequency spoiled 3-D volume MR scans were performed before, 4
to 6 days after, and up to 339 days after transplantation (13 allograf
ts, two autografts). A subvoxel registration program was used to match
the volume images precisely so that small changes could be detected a
fter subtraction of scans. Five healthy adult control subjects were al
so studied on two occasions 1 month apart. RESULTS: Studies performed
4 to 339 days after transplantation showed ventricular enlargement and
cortical atrophy in all 13 patients who had allografts. The changes w
ere evident at 4 to 6 days after transplantation and became more obvio
us during later follow-up examinations, Similar changes were seen in o
ne patient with an autograft but no significant change was seen in the
other patient with an autograft or in the five control subjects. Accu
rately registered volume scans were more sensitive than unregistered c
onventional scans in detecting early (9/10 versus 0/10), intermediate
(12/13 versus 3/12), and late (10/10 versus 4/9) ventricular enlargeme
nt on follow-up examinations. The same applied to cortical atrophy (9/
10 versus 0/10, 12/13 versus 0/12, and 10/10 versus 0/9.) CONCLUSION:
The specific cause and clinical significance of these changes are unce
rtain. Subvoxel registration of serial MR images may reveal changes th
at are poorly seen or not apparent on conventional scans.