PHARMACOPHORIC REQUIREMENTS FOR CANNABINOID SIDE-CHAINS - NAPHTHOYL AND NAPHTHYLMETHYL SUBSTITUTED DELTA(8)-TETRAHYDROCANNABINOL ANALOGS

Authors
PAPAHATJIS DP KOUROULI T MAKRIYANNIS A
Citation
Dp. Papahatjis et al., PHARMACOPHORIC REQUIREMENTS FOR CANNABINOID SIDE-CHAINS - NAPHTHOYL AND NAPHTHYLMETHYL SUBSTITUTED DELTA(8)-TETRAHYDROCANNABINOL ANALOGS, Journal of heterocyclic chemistry, 33(3), 1996, pp. 559-562
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
33
Issue
3
Year of publication
1996
Pages
559 - 562
Database
ISI
SICI code
0022-152X(1996)33:3<559:PRFCS->2.0.ZU;2-P
Abstract
We have synthesized hybrids of classical cannabinoids and aminoalkylin doles by combining the dibenzopyran structure of Delta(8)-tetrahydroca nnabinol with the ketonaphthyl or 1-naphthylmethyl moieties found in a minoalkylindoles in order to investigate the role of the ketonaphthyl and 1-naphthylmethyl pharmacophores in cannabimimetic activity.