RING-CHAIN TRANSFORMATION OF GAMMA-KETO-DELTA-CROTONOLACTONES - A CONVENIENT SYNTHESIS OF 1,4-PIPERAZINONES, 1,4-THIAZINONES AND 1,4-DIAZEPINONES

Authors
APOSTOLOPOULOS CD GEORGIADIS MP COULADOUROS EA
Citation
Cd. Apostolopoulos et al., RING-CHAIN TRANSFORMATION OF GAMMA-KETO-DELTA-CROTONOLACTONES - A CONVENIENT SYNTHESIS OF 1,4-PIPERAZINONES, 1,4-THIAZINONES AND 1,4-DIAZEPINONES, Journal of heterocyclic chemistry, 33(3), 1996, pp. 703-708
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
33
Issue
3
Year of publication
1996
Pages
703 - 708
Database
ISI
SICI code
0022-152X(1996)33:3<703:RTOG-A>2.0.ZU;2-B
Abstract
A new procedure for the efficient synthesis of 1,4-piperazinones, 1,4- thiazinones and 1,4-diazepinones is presented. The reaction is based o n a ring chain transformation of gamma-keto-delta-crotonolactones indu ced by 1,2- or 1,3-diamino- (or thiamino-) binucleophiles. The reactio n sequence of this transformation is also discussed.