Ea. Couladouros et al., HETEROANNULATION OF NAPHTHOQUINONES - STUDIES ON THE REACTION OF 2-BROMO-2,3-DIHYDRONAPHTHOQUINONE DERIVATIVES WITH 1,2-BINUCLEOPHILES, Journal of heterocyclic chemistry, 33(3), 1996, pp. 709-714
Heterocyclic derivatives of naphthoquinones were synthesized via their
2-bromo-2,3-dehydro-intermediates. This new route may lead to the for
mation of benzo[a]phenothiazin-5-ones, benzo[f]quinoxalin-6-ones as we
ll as their 1,4 (or 7,10) dihydroxy-derivatives in high yields. The po
ssible mechanisms involved in the formation of these compounds are dis
cussed.