SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 4-(ISOXAZOLINYL OR 1,2,4-OXADIAZOLYL) COUMARINS

Reaction of compound 3 with nitrile oxide 4a affords compounds 5a and 6 in 73% and 3% yield respectively, while reaction of 3 with 48 afford s only compound 5b (85%). Reactions of compound 8 with the nitrile oxi des 4a,b result in compounds 9a,b. The compound 10, prepared from 1 an d O-methylhydroxylamine, reacts with nitrile oxide 4b to give the oxad iazole derivative 12. The above referred coumarins are screened for an tiinflammatory activity in vivo using the carrageenin rat paw edema an d in vitro through their antiproteolytic activity and their ability to inhibit beta-glucuronidase and 12-Lipoxygenase.