JUVENILE XANTHOGRANULOMAS - A REVIEW OF 4 CASES

Four cases of juvenile xanthogranuloma are reported, One patient had a papulonodular lesion at birth and developed additional papulonodules during the first two years of life, after which spontaneous regression of the lesions occurred, The other three patients each had a single n odular lesion, These four cases illustrated the-histologic variants of juvenile xanthogranuloma, histiocytic cells with an eosinophilic cyto plasm predominated in cases 3 and 4, foam cells predominated in cases 1 and 2, and very large numbers of multinucleate giant cells were seen in case 2, Immunohistochemical studies demonstrated expression of CD6 8 and vimentin by the dermal infiltrate; S100 protein was expressed on ly in case 3, An ultrastructural study was done in case 1 and found th e main cytoplasmic markers classically present in juvenile xanthogranu lomas. Our results and the data from the literature emphasize that rig orous analysis of clinical and pathologic features is essential to the diagnosis of juvenile xanthogranuloma.