TREATMENT OF EXPERIMENTAL MOUSE BLADDER-TUMOR BY LPS-INDUCED EPITHELIAL-CELL SHEDDING

The purpose of the present study was to explore the therapeutic potent ial of serial administration of shedding- inducing endotoxin in a mous e tumour bladder model. The studies were conducted with two variants d erived from the MBT-2 tumour namely, T5 and T50, the latter being far more aggressive than the former. It was found that T5 tumours responde d to intravesical lipopolysaccharides (LPS) instillation by a consider able reduction in their pace of growth (P < 0.0001) when treatment was initiated 3 days after tumour implantation, but not when started afte r 7 days. The T50 variant did not respond to LPS when treated 3 days a fter implantation, but a considerable reduction in rate of growth occu rred when treatment was started after 1-2 days. Shedding induced by in travesically instilled LPS was found to retard considerably the progre ssion rate of experimental bladder tumour.