DIRECT SYNTHESIS OF KETO NITROALIPHATICS VIA RETRO-HENRY REACTION OF CYCLIC 2-NITROALCOHOLS BY ANHYDROUS COPPER-SULFATE ADSORBED ON SILICA-GEL - A SHORT SYNTHESIS OF (+ -)-PHORACANTHOLIDE-I/

Authors
SAIKIA AK HAZARIKA MJ BARUA NC BEZBARUA MS SHARMA RP GHOSH AC
Citation
Ak. Saikia et al., DIRECT SYNTHESIS OF KETO NITROALIPHATICS VIA RETRO-HENRY REACTION OF CYCLIC 2-NITROALCOHOLS BY ANHYDROUS COPPER-SULFATE ADSORBED ON SILICA-GEL - A SHORT SYNTHESIS OF (+ -)-PHORACANTHOLIDE-I/, Synthesis, (8), 1996, pp. 981
Citations number
46
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
8
Year of publication
1996
Database
ISI
SICI code
0039-7881(1996):8<981:DSOKNV>2.0.ZU;2-V
Abstract
It has been observed that anhydrous CuSO4 adsorbed on silica gel effec ts the C-C bond cleavage between the hydroxy group and the nitro group of 2-nitroalcohols. In the case of 2-nitrocyclohexanols, the products are RCO(CH2)(4)CH2NO2 where R is alkyl, aryl, etc. This strategy has been applied for a short synthesis of (+/-)-phoracantholide I.