Treatment of ethyl alpha-fluoroalkylacetates 1 or ethyl 3-fluoroalkyl-
2-iodoacrylates 2 under mild conditions with amidine affords 2-substit
uted 6-fluoroalkylpyrimidin-4(3H)-ones 4, 5, 6, 7 in excellent yields,
while alpha-fluoroalkyl alkyl ketones or alpha-fluoroalkyl aldehyde 3
give polysubstituted 6-fluoroalkylpyrimidines 8, 9 under the same con
ditions.