SYNTHESIS OF 2-SUBSTITUTED 6-FLUOROALKYLPYRIMIDIN-4(3H)-ONES AND 6-FLUOROALKYLPYRIMIDINES

Authors
GUAN HP HU QS HU CM
Citation
Hp. Guan et al., SYNTHESIS OF 2-SUBSTITUTED 6-FLUOROALKYLPYRIMIDIN-4(3H)-ONES AND 6-FLUOROALKYLPYRIMIDINES, Synthesis, (8), 1996, pp. 997
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
8
Year of publication
1996
Database
ISI
SICI code
0039-7881(1996):8<997:SO26A6>2.0.ZU;2-N
Abstract
Treatment of ethyl alpha-fluoroalkylacetates 1 or ethyl 3-fluoroalkyl- 2-iodoacrylates 2 under mild conditions with amidine affords 2-substit uted 6-fluoroalkylpyrimidin-4(3H)-ones 4, 5, 6, 7 in excellent yields, while alpha-fluoroalkyl alkyl ketones or alpha-fluoroalkyl aldehyde 3 give polysubstituted 6-fluoroalkylpyrimidines 8, 9 under the same con ditions.