SYNTHESIS OF 4-SUBSTITUTED-1,4-DIHYDROPYRIDINES

A general synthesis of C-4-substituted dihydropyridines is described. The route exploits a standard Hantzsch ester synthesis followed by nuc leophilic substitution of a halide with, for example, triethylphosphit e. The resulting compounds could have interesting biological propertie s or may find use as haptens for preparing catalytic antibodies for hy dride transfer reactions. Copyright (C) 1996 Published by Elsevier Sci ence Ltd