POEPOP AND POEPS - INERT POLYETHYLENE-GLYCOL CROSS-LINKED POLYMERIC SUPPORTS FOR SOLID SYNTHESIS

Two types of macromonomers were synthesized by reacting mono/di sodium derivatives of polyethylene glycol(1500) with vinylbenzyl chloride an d epichlorohydrin. These monomers were hulk homo-polymerized by free-r adical or anionic polymerization, respectively, to afford two differen t types of crosslinked polymeric supports in high yield. The resins we re tested for solid-phase peptide synthesis by standard Fmoc/OPfp/Dhbt method, using a Rink amide linker. The peptides were cleaved from the support using 95%TFA-H2O in high yield and purity. The pure peptides were characterized by MALDI-TOF mass spectrometry and and amino acid a nalysis. Copyright (C) 1996 Elsevier Science Ltd