We conducted a population-based study of amyotrophic lateral sclerosis
(ALS) in King, Pierce, and Snohomish counties in western Washington s
tate. Between April 1, 1990 and March 31, 1995, neurologists diagnosed
235 patients with ALS, including 127 men (54%) and 108 women (46%). T
he incidence rate, age-adjusted to the 1990 total U.S. population, was
higher for men at 2.1 per 100,000 per year (95% CI, 1.3 to 2.9) than
for women at 1.9 (95% CI, 1.1, 2.7) and increased with age for both me
n and women. These incidence rates are consistent with other studies f
rom northern latitudes.