IDEBENONE IMPROVES CEREBRAL MITOCHONDRIAL OXIDATIVE-METABOLISM IN A PATIENT WITH MELAS

Authors
IKEJIRI Y MORI E ISHII K NISHIMOTO K YASUDA M SASAKI M
Citation
Y. Ikejiri et al., IDEBENONE IMPROVES CEREBRAL MITOCHONDRIAL OXIDATIVE-METABOLISM IN A PATIENT WITH MELAS, Neurology, 47(2), 1996, pp. 583-585
Citations number
13
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
47
Issue
2
Year of publication
1996
Pages
583 - 585
Database
ISI
SICI code
0028-3878(1996)47:2<583:IICMOI>2.0.ZU;2-R
Abstract
We report a 36-year-old man with MELAS in whom a 5-month course of hig h-dose oral idebenone, a derivative of coenzyme Q(10), increased marke dly cerebral metabolic ratio of oxygen and oxygen extraction fraction without increased cerebral blood flow with PET. The results indicate t hat idebenone improves mitochondrial oxidative metabolism in the brain and suggest a therapeutic potential of idebenone for MELAS.