SINGLET OXYGEN OXIDATION OF PYRROLES - SYNTHESIS AND CHEMICAL-TRANSFORMATIONS OF NOVEL 4,4-BIS(TRIFLUOROMETHYL)IMIDAZOLINE ANALOGS

Authors
LI HY DRUMMOND S DELUCCA I BOSWELL GA
Citation
Hy. Li et al., SINGLET OXYGEN OXIDATION OF PYRROLES - SYNTHESIS AND CHEMICAL-TRANSFORMATIONS OF NOVEL 4,4-BIS(TRIFLUOROMETHYL)IMIDAZOLINE ANALOGS, Tetrahedron, 52(34), 1996, pp. 11153-11162
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
34
Year of publication
1996
Pages
11153 - 11162
Database
ISI
SICI code
0040-4020(1996)52:34<11153:SOOOP->2.0.ZU;2-X
Abstract
A novel singlet oxygen ring cleavage of pyrrole 5a and subsequent acid -catalyzed facile dehydrocyclization afforded a new series of 4,4-bis( trifluoromethyl)imidazolines with a p-fluorophenacyl side chain at the 5-position, which have shown potent acyl CoA: cholesterol acyltransfe rase (ACAT) and cholesterol biosynthesis inhibitory activities. Copyri ght (C) 1996 The DuPont Merck Pharmaceutical Company.