A 13-year-old Japanese girl presented with severe anemia and renal dys
function. The nephronophthisis-medullary cystic disease complex was di
agnosed from the results of renal biopsy and a family study. Immunohis
tochemical detection of hepatocyte growth factor in the epithelial cel
ls of dilated renal tubules suggested that it may have a role in the d
evelopment of the tubular cystic changes which are characteristic of t
his disease.