PREVENTION BY CYCLOHEXIMIDE OF THE AUDIOGENIC-SEIZURES AND TRYPTOPHANMETABOLIC DISTURBANCES OF ETHANOL WITHDRAWAL IN RATS

Authors
ORETTI R BANO S MORGAN CJ BADAWY AAB BONNER A BUCKLAND P MCGUFFIN P
Citation
R. Oretti et al., PREVENTION BY CYCLOHEXIMIDE OF THE AUDIOGENIC-SEIZURES AND TRYPTOPHANMETABOLIC DISTURBANCES OF ETHANOL WITHDRAWAL IN RATS, Alcohol and alcoholism, 31(3), 1996, pp. 243-247
Citations number
11
Categorie Soggetti
Substance Abuse
Journal title
Alcohol and alcoholism → ACNP
ISSN journal
07350414
Volume
31
Issue
3
Year of publication
1996
Pages
243 - 247
Database
ISI
SICI code
0735-0414(1996)31:3<243:PBCOTA>2.0.ZU;2-P
Abstract
Cycloheximide (20 mg/kg body wt, given intraperitoneally at -1 and 3 h after withdrawal of an ethanol-containing liquid diet) prevents the a ctivation of liver tryptophan pyrrolase, the consequent inhibition of synthesis of brain 5-hydroxytryptamine, and the audiogenic seizures ob served at 7 h after alcohol withdrawal. We suggest that a rapidly-turn ing-over protein mediates the alcohol withdrawal syndrome and discuss the possible role of liver tryptophan pyrrolase.