R. Oretti et al., PREVENTION BY CYCLOHEXIMIDE OF THE AUDIOGENIC-SEIZURES AND TRYPTOPHANMETABOLIC DISTURBANCES OF ETHANOL WITHDRAWAL IN RATS, Alcohol and alcoholism, 31(3), 1996, pp. 243-247
Cycloheximide (20 mg/kg body wt, given intraperitoneally at -1 and 3 h
after withdrawal of an ethanol-containing liquid diet) prevents the a
ctivation of liver tryptophan pyrrolase, the consequent inhibition of
synthesis of brain 5-hydroxytryptamine, and the audiogenic seizures ob
served at 7 h after alcohol withdrawal. We suggest that a rapidly-turn
ing-over protein mediates the alcohol withdrawal syndrome and discuss
the possible role of liver tryptophan pyrrolase.