SIMULTANEOUS DETERMINATION OF NORFLOXACIN AND TINIDAZOLE IN PHARMACEUTICAL PREPARATIONS BY HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY

A new simple, precise, rapid, and selective HPTLC method has been deve loped for simultaneous determination of norfloxacin and tinidozole in pharmaceutical formulations, The stationary phase was silica gel 60 F- 254 prewashed with ammoniacal methanol; n-butanol - ethyl alcohol - 12 .5% ammonia (4 + 1 + 2.2, v/v) was used as mobile phase. Detection and quantification were performed densitometrically at lambda = 293 nm, T he linearity ranges were 10-200 ng and 15-300 ng for norfloxacin and t inidazole, respectively; the respective percentage recoveries were 99. 94% and 100.13%.