THE EFFECT OF SULFUR MUSTARD ON GLUTATHIONE LEVELS IN RAT LUNG SLICESAND THE INFLUENCE OF TREATMENT WITH ARYLTHIOLS AND CYSTEINE ESTERS

Authors
LANGFORD AM HOBBS MJ UPSHALL DG BLAIN PG WILLIAMS FM
Citation
Am. Langford et al., THE EFFECT OF SULFUR MUSTARD ON GLUTATHIONE LEVELS IN RAT LUNG SLICESAND THE INFLUENCE OF TREATMENT WITH ARYLTHIOLS AND CYSTEINE ESTERS, Human & experimental toxicology, 15(8), 1996, pp. 619-624
Citations number
16
Categorie Soggetti
Toxicology
Journal title
Human & experimental toxicology → ACNP
ISSN journal
09603271
Volume
15
Issue
8
Year of publication
1996
Pages
619 - 624
Database
ISI
SICI code
0960-3271(1996)15:8<619:TEOSMO>2.0.ZU;2-7
Abstract
1 Sulphur mustard reacts directly with benzenethiols and cysteine este rs in aqueous medium. 2 Benzenethiols diffuse into lung slices in shor t term culture. 3 Treatment of lung slices in short term culture with benzenethiols does not protect cellular glutathione from conjugation w ith sulphur mustard. 4 Following uptake of cysteine ester into lung sl ices cysteine is elevated but this does not protect cellular glutathio ne from sulphur mustard.