EFFECTS OF CISPLATIN ON TESTICULAR TISSUE AND THE LEYDIG CELL-PITUITARY AXIS

Citation
A. Aydiner et al., EFFECTS OF CISPLATIN ON TESTICULAR TISSUE AND THE LEYDIG CELL-PITUITARY AXIS, Oncology, 54(1), 1997, pp. 74-78
Citations number
12
Categorie Soggetti
Oncology
Journal title
ISSN journal
00302414
Volume
54
Issue
1
Year of publication
1997
Pages
74 - 78
Database
ISI
SICI code
0030-2414(1997)54:1<74:EOCOTT>2.0.ZU;2-K
Abstract
The mechanisms responsible for the rapid increases in levels of gonado tropin and steroid hormones upon administration of cisplatin to rats a re not clearly understood. In the present study, the morphologic effec ts of cisplatin on the testis and the relationship of these changes to serum hormone levels were studied in adult rats. Upon administration of a single dose (5 mg/kg) of cisplatin, the levels of testosterone in the peripheral blood decreased and the level of luteinizing hormone ( LH) increased. After 3 days, significant damage to the germinal epithe lium became detectable by morphologic examination. In Leydig and Serto li cells, dilatation of the endoplasmic reticulum, structural changes in mitochondria and an increase in the numbers of inclusion bodies wer e detected. Although blood-testis barriers between Sertoli cells were normal, the relationship between germinal cells and the relationship b etween germinal cells and Sertoli cells were distorted. It is conclude d that damage to Leydig cells and withdrawal of the controlling effect s of the germinal epithelium on the LH-Leydig cell axis could explain the changes in serum hormone levels.