CERTAIN WITHANOLIDES FROM IOCHROMA GESNERIOIDES ANTAGONIZE ECDYSTEROID ACTION IN A DROSOPHILA-MELANOGASTER CELL-LINE

Authors
DINAN L WHITING P ALFONSO D KAPETANIDIS I
Citation
L. Dinan et al., CERTAIN WITHANOLIDES FROM IOCHROMA GESNERIOIDES ANTAGONIZE ECDYSTEROID ACTION IN A DROSOPHILA-MELANOGASTER CELL-LINE, Entomologia experimentalis et applicata, 80(2), 1996, pp. 415-420
Citations number
18
Categorie Soggetti
Entomology
Journal title
Entomologia experimentalis et applicata → ACNP
ISSN journal
00138703
Volume
80
Issue
2
Year of publication
1996
Pages
415 - 420
Database
ISI
SICI code
0013-8703(1996)80:2<415:CWFIGA>2.0.ZU;2-1
Abstract
Sixteen withanolides isolated from Iochroma gesnerioides (Kunth) Miers (Solanaceae) have been assessed for their activities as ecdysteroid a gonists and antagonists. None of the compounds showed any agonistic ac tivity, but several showed significant antagonistic activity. With a 2 0-hydroxyecdysone concentration of 5 x 10(-8) M, the ED(50) values for 2,3-dihydro-3 xi-methoxywithaferin A, 2,3-dihydro-3 xi-methoxywithacn istine, 2,3-dihydro-3 xi-methoxyiochromolide and 2,3-dihydro-3 xi-hydr oxywithacnistine are 3.5 x 10(-5) M, 1 x 10(-5) M, 5 x 10(-6) M and 2. 5 x 10(-6) M, respectively.