T(9-13)(Q34-Q12) CHROMOSOMAL TRANSLOCATION PERSISTING 4 YEARS POST AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR SECONDARY AML DESPITE MORPHOLOGICAL REMISSION

Authors
MAHENDRA P RICHARDS EM SINCLAIR P NACHEVA E MARCUS RE
Citation
P. Mahendra et al., T(9-13)(Q34-Q12) CHROMOSOMAL TRANSLOCATION PERSISTING 4 YEARS POST AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR SECONDARY AML DESPITE MORPHOLOGICAL REMISSION, Clinical and laboratory haematology, 18(2), 1996, pp. 121-122
Citations number
12
Categorie Soggetti
Hematology
Journal title
Clinical and laboratory haematology → ACNP
ISSN journal
01419854
Volume
18
Issue
2
Year of publication
1996
Pages
121 - 122
Database
ISI
SICI code
0141-9854(1996)18:2<121:TCTP4Y>2.0.ZU;2-K
Abstract
A 42-year-old male patient with a history of occupational exposure to benzene presented with pancytopenia. His bone marrow showed evidence o f trilineage dysplasia and cytogenetic analysis revealed a unique t(9; 13)(q34:q12) translocation. Five months after diagnosis he developed s econdary AML. He was treated with four courses of chemotherapy and an autologous bone marrow transplantation (BMT). Four years post-transpla ntation he remains in haematological and morphological remission thoug h the cytogenetic abnormality is still present in all metaphases exami ned.