Ceramide-1-phosphate sugars were synthesized by direct glycosyl phosph
ite/phosphate and O-glycosyl trichloroacetimidateiphosphate exchange r
eactions, respectively. Thus, ceramide-1-O-phosphoric acid 5 gave with
sialyl phosphite 1 as sialyl donor directly beta-linked sialyl phosph
ate 6; deprotection afforded the corresponding glycophospholipid ceram
ide-1-phosphate N-acetylneuraminate 7. Similarly, from O-glucosyl- and
O-galactosyltrichloroacetimidate 10 and 13 with phosphoric acid deriv
ative 5 glycosyl ceramide-1-phosphate sugars 12 and 15, respectively,
were obtained.