A NOVEL METHOD FOR GLYCOCONJUGATE SYNTHESIS

2-Chloroethyl 1-thio-beta-D-galactopyranoside and the corresponding 1- thio-beta-D-glucopyranoside have been found to be suitable glycosylati ng agents for the preparation of different types of glycoconjugates. G lycosylation of bovine serum albumin and chymotrypsin were chosen as e xamples of an application of the described compounds. The glycosylatin g agents can modify not only amino groups, but also alkyl hydroxyl and aryl hydroxyl groups, as was shown in experiments with model water so luble and water insoluble polyacrylamide copolymers.