A. Lafuente et Ai. Esquifino, HYPERPROLACTINEMIA AND CYCLOSPORINE TREATMENT ON SECRETION OF ADENOHYPOPHYSEAL HORMONES, Life sciences, 59(12), 1996, pp. 993-1000
Citations number
26
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
The possibility of interactions between the effects of cyclosporine (C
yA) and prolactin to regulate various physiological functions has been
suggested. To further analyze these interactions, the effect of chron
ic CyA administration on the secretion of adenohypophyseal hormones in
hyperprolactinemic male rats, was studied. Male rats were grafted one
pituitary gland under the kidney capsule or were sham-operated at 30
days of age. Both pituitary-grafted and sham-operated rats were given
s.c. injections of vehicle or CyA (5mg/kg/day) for 30 days beginning o
n the day of surgery. Pituitary-grafting increased the plasma leveles
of prolactin and decreased the plasma levels of luteinizing hormone (L
H), whereas growth hormone (GH), thyroid stimulating hormone (TSH) and
follicle stimulating hormone (FSH) did not change. CyA treatment to s
ham-operated rats did not modify plasma prolactin levels and decreased
plasma levels of GH and LH. Administration of the immunosuppressor to
pituitary-grafted rats decreased plasma prolactin levels and augmente
d plasma levels of LH and FSH. Plasma TSH levels did not change after
CyA treatment either in sham-operated or in pituitary-grafted rats. Th
ese data suggest that CyA may modify the effects induced by prolactin
on pituitary hormone secretion, although direct effects of the drug on
the hypothalamic-pituitary axis cannot be excluded, according to the
data obtained in sham-operated rats.