DISSOLUTION TESTING OF ARTEMISININ SOLID ORAL DOSAGE FORMS

Dissolution can best be described as a tool that can provide valuable information about the bioavailability of a drug product. But to obtain a good overall correlation with in vivo data, the presence of sink co nditions is an essential requirement in the dissolution tests. The flo w-through cell method has been recommended to be a dissolution method that most satisfactorily fulfils this requirement for poorly water sol uble drugs. The present article demonstrates that in case of artemisin in, a hydrophobic compound used in high dose per tablet or capsule, ev en the flow-through cell method does not guarantee the presence of sin k conditions during the total duration of the experiments.