INDURATIO PENIS PLASTICA - EFFECTIVITY OF LOW-DOSE RADIOTHERAPY AT DIFFERENT CLINICAL STAGES

This study describes the treatment of Peyronie's disease by means of l ow-dose radiotherapy. We treated 265 men aged 24.5-79.4 years (median = 57.7 years). No previous therapy had been carried out in 214 patient s, and 41 patients had been pretreated (systemic: potassium p-aminoben zoate, vitamins a, b, e; topical: corticosteroids, teleradiotherapy). The disease was classified using criteria proposed by Alth in 1984 loc ation, number and size of foci, hardness of fibromatous foci and axis deviation, potentia coeundi and pain were evaluated). Radiotherapy was performed by local application of a special iridium-192 moulage devel oped at our institute. In 66.4% of the monitored patient group (n = 15 5) therapy was successful. We obtained complete regression of the fibr omatous foci in 9% (n = 14), partial remission >50% in 29.7% (n = 46) and partial remission <50% in 27.7% (n = 43) of the patients. We found a significant correlation between hardness, size of the treated foci and therapeutic success. Eighty-three patients suffered from pain duri ng penile erection before therapy, and in 61.4% (n = 51) of these pati ents the pain disappeared after treatment. Moreover, the patients conf irmed that both loss of pain and regression of deviation related to fo ci regressions were correlated with improvement in erectile function. No serious side effects were observed in any of our patients.