IN-VITRO PROPERTIES OF A CHITOSAN-BONDED BONE-FILLING PASTE - STUDIESON SOLUBILITY OF CALCIUM-PHOSPHATE COMPOUNDS

The present study investigated properties of various mixtures of organ ic acids (malic and malonic) and calcium phosphate compounds (beta-tri calcium phosphate, ashed bovine bone, and synthetic hydroxyapatite) wi th the objective of determining the optimum combination of organic aci d and calcium phosphate compound for components of a chitosan-bonded b one-filling paste. beta-tricalcium phosphate was decomposed by malic a cid and malonic acid, but these two acids did not decompose synthetic hydroxyapatite and ashed bovine bone. Assessment of ion release from a set paste containing either synthetic hydroxyapatite or ashed bovine bone indicated that only calcium ions were appreciably released after storing and stirring the set paste in physiologic saline for 7 days. ( C) 1996 John Wiley & Sons, Inc.