Sulfadiazine anion exchange resin was prepared. Loading of the drug on
to the resin was accomplished by the batch process. Drug-resin samples
with different loaded concentrations were prepared. Microencapsulatio
n of the drug-resin complex was carried out adopting a modified water/
oil/water (W/O/W) complex emulsion technique. The results revealed tha
t Dowex 1-X8 (Cl-) can be used to prepare a drug-resin complex of sulf
adiazine. The prepared complex was of high loading and exhibited a pro
longed release profile of the drug. Microencapsulation of the complex
with prolonged release of the medicament can be also formulated.