A. Wennerberg et al., MIXED ERYTHROCYTE CHIMERISM - IMPLICATIONS FOR TOLERANCE OF THE DONORIMMUNE-SYSTEM TO RECIPIENT NON-ABO SYSTEM RED-CELL ANTIGENS, Bone marrow transplantation, 18(2), 1996, pp. 433-435
We report a case of a minor degree of ABO incompatibility in a BMT rec
ipient, demonstrating mixed RBC chimerism, who, late in the post-trans
plant period, developed a warm autoimmune hemolytic anemia and subsequ
ently developed antibodies with donor-anti-recipient specificities for
non-ABO system RBC antigens, While this implies a lack of tolerance o
f the donor immune system for recipient non-ABO system RBC antigens, o
ther factors may be operating and should be evaluated before such a co
nclusion is reached, Underscored is the importance of obtaining pretra
nsplant RBC antigen phenotypes on both the recipient and donor.