SUCCESSFUL TREATMENT OF SEVERE HEPATIC VENOOCCLUSIVE DISEASE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION BY TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC STENT-SHUNT (TIPS)

Severe veno-occlusive (VOD) disease is a major cause of morbidity and mortality in allogeneic bone marrow transplant recipients, and new app roaches in managing patients who develop serious VOD is needed, In thi s report, we describe a patient who underwent transjugular intrahepati c portosystemic stent-shunt (TIPS) for life-threatening VOD are follow ing allogeneic bone marrow transplantation for AML, Although the patie nt died of CMV-associated pneumonitis 5 weeks later, the TIPS function ed well until her death and permitted regression of the hepatic and re nal symptoms, This report suggests that TIPS may be feasible and effec tive for managing patients with life-threatening liver dysfunction aft er marrow transplantation.