UNUSUAL SPLIT CHIMERISM AFTER MISMATCHED T-DEPLETED BMT

Authors
TERENZI A AVERSA F MENCARELLI A PELICCI P VELARDI A PERRUCCIO K MARTELLI MF
Citation
A. Terenzi et al., UNUSUAL SPLIT CHIMERISM AFTER MISMATCHED T-DEPLETED BMT, Bone marrow transplantation, 18(2), 1996, pp. 465-467
Citations number
10
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
18
Issue
2
Year of publication
1996
Pages
465 - 467
Database
ISI
SICI code
0268-3369(1996)18:2<465:USCAMT>2.0.ZU;2-0
Abstract
We report a case of haploidentical T-depleted BMT that engrafted durab ly after a highly immunosuppressive conditioning regimen, DNA polymorp hism analysis showed that granulocytes and monocytes were donor type b ut T and B lymphocytes were host derived. Host tolerance to donor anti gens was documented. The patient suffered from serious recurrent CMV i nfections until split chimaerism shifted to full donor type 2 years po st-BMT. Seven years after BMT the patient remains in complete remissio n.