When non-surgical attempts prove unsuccessful or are contraindicated,
surgical endodontic therapy is needed to save the tooth. The procedure
usually consists of exposure of the involved area, root end resection
, root end preparation and insertion of a root end filling material. N
umerous materials have been suggested as root end filling materials. T
his article is a review of the literature on the suitability of variou
s root end filling materials based on their leakage assessment, margin
al adaptation, cytotoxicity, and usage test in experimental animals an
d humans.