LINKAGE MAP INTEGRATION

The algorithms that drive the map+ program for locus-oriented linkage mapping are presented. They depend on the enhanced location database p rogram ldb+ to specify an initial comprehensive map that includes all loci in the summary lod file. Subsequently the map may be edited or or der constrained and is automatically improved by estimating the locati on of each locus conditional on the remainder, beginning with the most discrepant loci. Operating characteristics permit rapid and accurate construction of linkage maps with several hundred loci. The map+ progr am also performs nondisjunction mapping with tests of nonstandard reco mbination. We have released map+ on Internet as a source program in th e C language together with the location database that now includes the LODSOURCE database. The anonymous ftp is cedar.genetics.soton.ac.uk a nd the World Wide Web address is http://cedar.genetics.soton.ac.uk/pub lic html. (C) 1996 Academic Press, Inc.