ASSIGNMENT OF HUMAN PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT GENES B56-ALPHA, B56-BETA, B56-GAMMA, B56-DELTA, AND B56-EPSILON (PPP2R5A-PPP2R5E), HIGHLY EXPRESSED IN MUSCLE AND BRAIN, TO CHROMOSOME REGIONS 1Q41, 11Q12, 3P21, 6P21.1, AND 7P11.2-]P12

The activity of the major intracellular protein phosphatase, protein p hosphatase 2A (PP2A), is determined by the nature of the associated re gulatory subunit. A new family of human PP2A regulatory subunits has r ecently been identified. Three of these subunits, B56 beta, R56 delta, and B56 epsilon, are most highly expressed in brain, while the B56 al pha and B56 gamma isoforms are highly expressed in cardiac and skeleta l muscle. Genes PPP2R5A-PPP2R5E encoding the phosphatase regulatory pr oteins B56 alpha, B56 beta, B56 gamma, B56 delta, and B56 epsilon have now been mapped by fluorescence in situ hybridization to chromosome r egions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12, respectively. (C ) 1996 Academic Press, Inc.