A NEW SODIUM-CHANNEL ALPHA-SUBUNIT GENE (SCN9A) FROM SCHWANN-CELLS MAPS TO THE SCN1A, SCN2A, SCN3A CLUSTER OF MOUSE CHROMOSOME-2

We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encodin g an alpha-subunit isoform of the sodium channel from Schwann cells, S cn9a. Linkage analysis established that Scn9a mapped to the proximal s egment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus X C57BL/6J back cross indicates that Scn9a is very tightly linked to Scn1a (gene encod ing the type I sodium channel alpha subunit of the brain) and forms pa rt of a cluster of four Scna genes located on mouse chromosome 2. (C) 1996 Academic Press, Inc.