PURE RED-CELL APLASIA AFTER MAJOR ABO-INCOMPATIBLE BONE-MARROW TRANSPLANTATION - 2 CASE-REPORTS OF TREATMENT WITH RECOMBINANT-HUMAN-ERYTHROPOIETIN

A 34-year-old man with acute myelocytic leukemia (AML : MO) and a 32-y ear-old woman with AML: M2 developed pure red cell aplasia (PRCA) afte r receiving a major ABO-incompatible bone marrow transplant (BMT). The first patient responded to recombinant human erythropoietin (rhEPO) t herapy, while the second did not. The second patient also received met hylprednisolone (m-PSL) but developed reticulocytosis and hemolysis af ter the administration of m-PSL, Plasmapheresis was then performed and the patient promptly recovered from hemolysis and PRCA. We conclude t hat close attention must be paid when treating PRCA following major AB O-incompatible BMT with rhEPO and m-PSL, as there is always the potent ial for massive hemolysis.