PRIMARY AND SECONDARY IMMUNE-RESPONSES TO LISTERIA-MONOCYTOGENES

Recent studies have revealed the complexity of cytokine and cellular i nteractions required for resistance to primary Listeria monocytogenes infection and have illustrated that resistance to secondary infection may occur through multiple pathways. Analyses of Listeria epitope gene ration and the specificity of protective CD8+ T cells have suggested t hat future research should focus on secreted protein antigens in speci fic resistance to infection and have increased our understanding of Li steria antigens presented by MHC class I-b molecules.