EFFECTS OF S-CMC ON THE CISPLATIN TOXICITY IN RATS

In the present study, some toxic effects of cisplatin are evaluated in rats. It was also investigated whether S-carboxymethylcysteine (S-CMC ), a free radical scavenger, protects the experimental animals from th e toxic effects of cisplatin. The 1st, 2nd, 4th and 5th groups receive d physiological saline, dimethyl sulphoxide, and S-CMC (100 and 500 mg /kg i.p.) for 3 days, respectively. The 3rd group received cisplatin ( 5 mg/kg i.p.) 12 h before sacrifice. The 6th and 7th groups received S -CMC (100 and 500 mg/kg i.p., respectively); additionally, these group s received cisplatin (5 mg/kg i.p.) 12 h before the rats were sacrific ed. 5 mg/kg cisplatin decreased significantly serum creatinine and glu tamic-oxaloacetic and glutamic-pyruvic transaminase levels as well as leucocyte counts. Although S-CMC did not change the effects of cisplat in on creatinine and liver enzyme levels, it eliminated the effect of cisplatin on leucocyte counts. Cisplatin increased significantly urina ry creatinine level and creatinine clearance. Cisplatin caused some hi stological changes in kidney and liver.