SIMPLE AND EFFICIENT SYNTHESIS METHOD OF RADIOIODINE-PHENYL-PENTADECANOIC ACID AND UPTAKE OF TISSUES OF ANIMALS

Fatty acid are the major energy source for the myocardium, thus radiol abeled fatty have often employed as heart imaging agent to localize is chemia and as potential probes of myocardial metabolism. This paper pr esents the synthesis of phenyl-pentadecanoic acid (PPA) by alkylation reaction and Wollf-Kishner method. Finally, PPA was iodinated with tha llium trifluoroacetate on localizing para- position of phenyl ring and radioiodine was exchanged. The overall chemical yield was 20%, labell ing yield 95%, radiochemical purity 98%. Tissues distribution of mice shows that IPPA was very high activity in mice heart muscle. Autoradio gram of mouse section al 2 min is clear.