THE EFFECT OF DEXRAZOXANE (ICRF-187) ON DOXORUBICIN-MEDIATED AND DAUNORUBICIN-MEDIATED GROWTH-INHIBITION OF CHINESE-HAMSTER OVARY CELLS

Dexrazoxane (ICRF-187) is clinically used to reduce doxorubicin-induce d cardiotoxicity. Because dexrazoxane, doxorubicin and daunorubicin al l act on DNA topoisomerase II, a study was undertaken to see what effe ct dexrazoxane had on the growth inhibitory effects of doxorubicin and daunorubicin towards Chinese hamster ovary cells. Dexrazoxane exhibit ed significant antagonism of doxorubicin- and daunorubicin-mediated gr owth inhibition when the cells were preincubated with dexrazoxane befo re the anthracycline was added. Continuous exposure of cells to either anthracycline and low concentrations of dexrazoxane resulted In addit ive growth inhibitory effects at low anthracycline concentrations, and no effect at higher anthracycline concentrations.