ONTOGENIC DEVELOPMENT OF THE RESPONSE TO ANANDAMIDE AND DELTA(9)-TETRAHYDROCANNABINOL IN MICE

Authors
FRIDE E MECHOULAM R
Citation
E. Fride et R. Mechoulam, ONTOGENIC DEVELOPMENT OF THE RESPONSE TO ANANDAMIDE AND DELTA(9)-TETRAHYDROCANNABINOL IN MICE, Developmental brain research, 95(1), 1996, pp. 131-134
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Developmental brain research → ACNP
ISSN journal
01653806
Volume
95
Issue
1
Year of publication
1996
Pages
131 - 134
Database
ISI
SICI code
0165-3806(1996)95:1<131:ODOTRT>2.0.ZU;2-1
Abstract
We studied the ontogenetic response to cannabinoid receptor ligands by measuring motor activity and analgesia in response to anandamide or D elta(9)-THC from day 6 of age. No response to anandamide was observed up to the age of weaning (day 23), while a nonsignificant response to Delta(9)-THC was observed starting between days 15 and 20. This is com patible with observations that children respond to the antiemetic effe cts of THC without psychotropic side effects.