FACILE NEW METHOD FOR PREPARATION OF OPTICALLY-ACTIVE PROTECTED PROLINE

Authors
YAMAGUCHI J UEKI M
Citation
J. Yamaguchi et M. Ueki, FACILE NEW METHOD FOR PREPARATION OF OPTICALLY-ACTIVE PROTECTED PROLINE, Chemistry Letters, (8), 1996, pp. 621-622
Citations number
8
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
8
Year of publication
1996
Pages
621 - 622
Database
ISI
SICI code
0366-7022(1996):8<621:FNMFPO>2.0.ZU;2-C
Abstract
Treatment of LN-protected 2-amino-5-bromopentanoic acid ester, which w as prepared from protected L-glutamic acid, with sodium hydride in tet rahydrofuran (THF) proceeded to give the corresponding protected L-pro line in high yield. On the other hand, the reaction of 2-aminobutyric acid derivative with sodium hydride gave the 1-aminocyclopropane-1-car boxylic acid derivative.