EQUILIBRIUM AND KINETIC-STUDIES OF COBALT(II) COMPLEXATION BY FOLIC-ACID

The equilibrium and kinetics of the complexation of Co-II by folic aci d have been studied at 25 degrees C, the ionic strength being regulate d with KNO3 in the 5.6-7.3 pH range. Kinetic studies were performed us ing the stopped-how method. Under our experimental conditions one proc ess was observed; a reaction which took place within a few seconds. Th e results are consistent with the formation of a 1:1 complex between t he reactants and a mechanism is proposed to account for the observed b ehaviour. Equilibrium constants for the Co-II and folic acid system, a s well as activation parameters, are reported.