Js. Caldwell et al., MOLECULAR-CLONING OF THE HUMAN RAD GENE - GENE STRUCTURE AND COMPLETENUCLEOTIDE-SEQUENCE, Biochimica et biophysica acta. Molecular basis of disease, 1316(3), 1996, pp. 145-148
We have isolated and sequenced human genomic DNA clones encoding the R
as-related GTP-binding protein, Rad. The gene spans 3.75 kb and consis
ts of five exons and four introns. Translation initiates from the firs
t of two in-frame methionine residues in the second exon. Several pote
ntial transcription cis-elements were revealed throughout the 1.7 kb 5
'-flanking region, including 'E box' and CArG binding sites for regula
tors of transcription in muscle.