EFFECT OF PIMOZIDE ON SELF-STIMULATION THRESHOLDS UNDER A CONTINUOUS AND FIXED-INTERVAL SCHEDULE OF REINFORCEMENT

Rats implanted with a monopolar electrode in the medial mesencephalon and trained to press a lever to self-administer trains of stimulating pulses were tested under a continuous (CRF) and a fixed interval (FI-1 s) schedule of reinforcement before and after systemic pimozide inject ion (0.35 mg/kg). As previously shown, this dose of pimozide caused re ductions in maximal response rates and in the rewarding effectiveness of the stimulation. The magnitude of the attenuation in rewarding effe ctiveness was significantly greater under CRF than under FI conditions , an effect that can be attributed to the decrease in the number of ea rned rewards concomitant to a decrease in response rates. The present results show that the tighter control over reward density provided by the use of a Fl schedule of reinforcement reduces the probability of a rtifactually measuring increases in reward thresholds following treatm ents that suppress response rates.