INVESTIGATION OF THE EFFECT OF TETRAHYDROAMINOACRIDINE ON TURNOVER KINETICS OF CAMEL (CAMELUS-DROMEDARIUS) RETINA ACETYLCHOLINESTERASE

Authors
ALJAFARI AA KAMAL MA
Citation
Aa. Aljafari et Ma. Kamal, INVESTIGATION OF THE EFFECT OF TETRAHYDROAMINOACRIDINE ON TURNOVER KINETICS OF CAMEL (CAMELUS-DROMEDARIUS) RETINA ACETYLCHOLINESTERASE, Biochemistry and molecular biology international, 39(5), 1996, pp. 917-922
Citations number
29
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
39
Issue
5
Year of publication
1996
Pages
917 - 922
Database
ISI
SICI code
1039-9712(1996)39:5<917:IOTEOT>2.0.ZU;2-X
Abstract
The effect of tetrahydroaminoacridine (THA) on turnover kinetics of ca mel retina acetylcholinesterase has been investigated. The turnover nu mber (K-cat) and specificity constant (K-sp) were 62.1 min(-1) and 9.9 2 x 10(5) (M. min)(-1) in the control system while the values for both parameters were lowered by 25-68% and 48-87% in the THA (0.05-0.4 mu M) treated systems respectively. Therefore, THA's effect on turnover n umber must be considered at the time of therapy to the Alzheimer's dis ease patients.