ESTROGEN SURGE - A REGULATORY SWITCH FOR SUPEROXIDE RADICAL GENERATION AT IMPLANTATION

Citation
M. Laloraya et al., ESTROGEN SURGE - A REGULATORY SWITCH FOR SUPEROXIDE RADICAL GENERATION AT IMPLANTATION, Biochemistry and molecular biology international, 39(5), 1996, pp. 933-940
Citations number
21
Categorie Soggetti
Biology
ISSN journal
10399712
Volume
39
Issue
5
Year of publication
1996
Pages
933 - 940
Database
ISI
SICI code
1039-9712(1996)39:5<933:ES-ARS>2.0.ZU;2-S
Abstract
This study is undertaken to identify the regulatory switch for the act ivation of superoxide radical generation pathway and repression of sup eroxide dismutase (SOD) at the time of implantation using estrogen as a control factor and delayed implantation as a model system. The resul ts revealed high SOD activity anl negligible oxyradical generation in progesterone-treated animals on day-5 and day-8 (delayed implantation) while an enormous rise in oxyradical generation and an abrupt fall in SOD in animals which received both estrogen and progesterone injectio ns were observed on days 5 and 8 of pregnancy. These results strongly suggest that estrogen regulates superoxide anion radical generation by lowering the SOD activity.