RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM OF THE HUMAN APO-B AND APO-AII GENE REGIONS AMONG TYPE-II DIABETICS

Levels of plasma low density lipoproteins (LDL) are positively, and hi gh density lipoproteins (HDL) are negatively correlated with an increa sed risk for atherosclerosis. The frequencies of restriction fragment length polymorphism (RFLP) of the genes for apoB, a major LDL apolipop rotein, and apoAII, a major HDL apolipoprotein, were studied in 45 Tun isian diabetics and an equal number of sex and age matched controls. S outhern blot analysis of an EcoR1 apoB polymorphism and an Msp1 apo AI I polymorphism indicates that there was no statictically significant d ifference in the incidence of different genotypes or alleles among dia betics compared to controls.